{"id":"https://openalex.org/G6182320931","display_name":"The Role of NLRP7 and KHDC3L in Germline Imprinting and Embryonic Reprogramming","description":"PUBLIC HEALTH RELEVANCE: Mutations in two genes, NLRP7 and KHDC3L cause recurrent biparental hydatidiform molar pregnancies (BiHM), in which the placenta is very abnormal and the fetus does not develop. We propose to examine how loss of function of these genes causes these abnormal pregnancies through studies in embryonic stem cell culture models. We will search for the proteins with which KHDC3L and NLRP7 interact and study how they cooperate to regulate the expression of many other genes to help us understand fundamental principles of the genetic regulation of reproduction and the causes of BiHM and other similar diseases.","funder_award_id":"R01HD079442","funder":{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi":"10.13039/100009633"},"funded_outputs":["https://openalex.org/W2465265090","https://openalex.org/W2601398223","https://openalex.org/W2755963975","https://openalex.org/W3093485243","https://openalex.org/W3192406625","https://openalex.org/W4236697448","https://openalex.org/W4316661399","https://openalex.org/W4386368528"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2015-03-01","end_date":"2022-02-28","start_year":2015,"end_year":2022,"landing_page_url":"https://reporter.nih.gov/project-details/9023570","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"IGNATIA B","family_name":"VAN DEN VEYVER","orcid":null,"role_start":null,"affiliation":{"name":"BAYLOR COLLEGE OF MEDICINE","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G6182320931","primary_topic":{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.7999,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.7999,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}