{"id":"https://openalex.org/G6180621114","display_name":"Development of Quantitative Cerebral Blood Flow and Oxygen Metabolism using O-17 Water and Oxygen Molecules","description":"Signal simulations for the various tissue were conducted using theoretical equations of MRI signals. Good correlations were noted between signal simulation and O-17 phantom signal, and conversion method from MRI signal to O-17 concentration was determined. Based on the MRI scans of normal volunteers, scan method with FSE sequence was established, and development of algorithm for quantitative analysis of cerebral blood flow.Manufacturing of O-17 oxygen was established, and inhalation apparatus of O-17 was designed. Smaller O-17 phantom was created, and MRI scans with animal MRI were performed. Good image contrast was obtained for marmosets with the administration of O-17 water.","funder_award_id":"26293269","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W27001394","https://openalex.org/W1888594577","https://openalex.org/W2026499262","https://openalex.org/W2265451556","https://openalex.org/W2322214940","https://openalex.org/W2326188275","https://openalex.org/W2441923858","https://openalex.org/W2522508504"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":16380000.0,"currency":"JPY","amount_usd":158479.06,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (B)","start_date":"2014-04-01","end_date":"2017-03-31","start_year":2014,"end_year":2017,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26293269/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kohsuke","family_name":"Kudo","orcid":null,"role_start":null,"affiliation":{"name":"Hokkaido University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000010374232","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5035360381","display_name":"Kohsuke Kudo","orcid":"https://orcid.org/0000-0001-5351-9242"},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G6180621114","primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6098,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6098,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}