{"id":"https://openalex.org/G50293126","display_name":"Integrative modeling of biological interfaces","description":"Molecular interfaces are essential for the formation and regulation of all assemblies that sustain life, to define cellular boundaries and intracellular organization, and to mediate communication with the outer environment. Although understanding their nature at atomic detail is fundamental to dissect fundamental biological mechanisms, they have been historically very challenging to study, especially when interfacial components are not amenable to structural determination as for membrane-bound proteins, or when stability is compromised upon purification as in certain protein-protein and protein-DNA complexes. Even when successful, high resolution techniques might produce incomplete or perturbed information and lack important dynamic features. Other methods can in turn provide complementary data, including dynamics, however they are often at lower resolution so that are not very informative of the underlying molecular mechanisms. The sparse, partial but complementary nature of all these kinds of data requires computational techniques to put together all pieces of information into consistent models able to advance our understanding of biological function. My laboratory has a long-standing trajectory in the development and application of these methods, collectively known as integrative modeling. In this grant we propose a research program to push the boundaries of the field of integrative modeling with developments aimed at (i) exploring the physics of the relevant biological interfaces using molecular simulations in order to develop scoring functions able to treat intermolecular interactions more accurately and to account for their conformational dynamics; and (ii) better integrating experimental inputs, especially those originated from the growing body of cryo-EM data at diverse resolutions, to define relevant molecular models. These new advancements will be tested and applied to systems relevant for their involvement in fundamental biological processes and development of society-threatening pathologies.","funder_award_id":"192371","funder":{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi":"10.13039/501100001711"},"funded_outputs":["https://openalex.org/W3186963476","https://openalex.org/W3201877532","https://openalex.org/W4307447233","https://openalex.org/W4366279959","https://openalex.org/W4387439961","https://openalex.org/W4388598784","https://openalex.org/W4392740412","https://openalex.org/W4394727493","https://openalex.org/W4400985732","https://openalex.org/W4403824354","https://openalex.org/W4403873873","https://openalex.org/W4411730430","https://openalex.org/W4412100588","https://openalex.org/W4416102890"],"funded_outputs_count":14,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":764216.0,"currency":"CHF","amount_usd":791127.05,"amount_usd_basis":"daily_rate","recipients":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","roles":["lead"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"}],"recipient_countries":[{"country_code":"CH","share":1.0,"amount_usd":791127.05,"basis":"organisation_location"}],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Project funding","start_date":"2020-04-01","end_date":"2025-03-31","start_year":2020,"end_year":2025,"landing_page_url":"https://data.snf.ch/grants/grant/192371","doi":null,"provenance":"snsf","lead_investigator":{"given_name":"Dal Peraro,","family_name":"Matteo","orcid":null,"role_start":null,"affiliation":{"name":"EPF Lausanne \u2013 EPFL","country":"Switzerland","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G50293126","primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.6259,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.6259,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"updated_date":"2026-11-05T03:01:09.000Z","created_date":"2026-07-13T04:27:35.000Z"}