{"id":"https://openalex.org/G4920280830","display_name":"Evolution of Siglec-11 in primates","description":"Sialic acids are a family of nine-carbon sugars that are found at the terminal end of glycan chains on cell surface. Siglec-11 is a sialic-acid receptor that gained expression on brain microglia uniquely in the human lineage, and shows a neuroprotective function in brain immunity. It seems that Siglec-11 contributed to brain evolution in the human lineage.Evolutionary analysis of Siglec-11 revealed that Siglec-11 functions as paired receptors with Siglec-16 on human brain microglia. Both Siglec-11 and Siglec-16 recognize oligo-sialic acids, which are enriched in the brain. A mutation that conferred the brain expression of Siglec-11 occurred about one million years ago. It is therefore possible to consider that Siglec-11/Siglec-16 paired receptors contributed to the gain of human-specific cell-cell communication in the brain in the later stage of human evolution.","funder_award_id":"23570271","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2110088555","https://openalex.org/W2770509454","https://openalex.org/W2892722395"],"funded_outputs_count":3,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":5460000.0,"currency":"JPY","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":null,"end_date":null,"start_year":null,"end_year":null,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23570271/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"TOSHIYUKI","family_name":"HAYAKAWA","orcid":null,"role_start":null,"affiliation":{"name":"Kyushu University(2013)Kyoto University(2011-2012)","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000080418681","type":"nrid","asserted_by":"kaken"}]}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4920280830","primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.8816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.8816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210129581","display_name":"Kyoto University of Education","ror":"https://ror.org/03zhhr656","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210129581"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-07-13T04:17:19.000Z"}