{"id":"https://openalex.org/G4875165537","display_name":"Mechanisms of accumulation, elimination and disturbances of the nervous and endocrine systems induced by chlordecone in Macrobrachium rosenbergii in the French West Indies.","description":"In the French West Indies, chlordecone was used on bananas till the beginning of the \u201890s. This resulted in a highly persistent contamination of soils, water and living organisms. In freshwater environments, crustaceans present high concentrations of chlordecone in their organs. Therefore, more severe controls have been made on farms that produce the giant river prawn (Macrobrachium rosenbergii). As the result, the analysis showed that, in several aquaculture farms of Guadeloupe and Martinique, chlordecone levels in the shrimps was over the maximal limit of residues established at 20 \u00b5g/kg. Up to now, the studies designed to tackle this problem only addressed the level of contamination of freshwaters and crustaceans, and empirically observed changes in populations of aquatic animals (crustaceans and fish) in contaminated rivers. Many questions remained unsolved regarding the route of entry of chlordecone in the shrimps, on the bioavailability of the compound in freshwater ecosystems, and the capabilities of the shrimps to biotransform and eliminate residues. In addition, intoxication mechanisms which could results in chlordecone-induced alterations of the nervous and endocrine systems remain poorly understood in these invertebrates, so that specific biomarkers of exposure and toxic effects are not available yet. In the MACHLOMA project, which will benefit of interactions with aquaculture farms in Guadeloupe, we propose to use Macrobrachium rosenbergii as a model species to increase the knowledge on (i) the mechanisms of bioconcentration/bioaccumulation of chlordecone, by comparison with the concentrations measured in environmental matrices (water, sediments, particulate materials), (ii) the enzymatic mechanisms of detoxication and depuration of chlordecone, and (iii) the mechanisms of neurotoxicity and endocrine disruption, which are known to occur in mammals. Experiments will be performed (i) in control and contaminated ponds used for shrimp production in local aquaculture farms and (ii) in the laboratory, in order to build concentration-response relations based on environmental realistic exposure concentrations (which can reach 0.5 to 10 \u00b5g/L in some locations). Integration of the information acquired on these mechanisms will be facilitate by the use of the same individuals for both residue measurements, detoxication/depuration studies, and effects analysis. Acquisition of a sound knowledge on the fate and effects of chlordecone in M. rosenbergii will be of primary importance (i) to contribute to solve the problem the aquaculture is currently facing in the French West Indies and to propose solutions to maintain this activity which is important in the local economy, and (ii) to identify relevant biomarkers that could be transferred to species naturally present in rivers (e.g., Macrobrachium faustinum) and used for risk assessment and remediation in natural freshwater ecosystems.","funder_award_id":"ANR-10-CESA-0014","funder":{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","doi":"10.13039/501100001665"},"funded_outputs":["https://openalex.org/W27108204","https://openalex.org/W2077878418","https://openalex.org/W2325639431","https://openalex.org/W2478452010","https://openalex.org/W2605220239","https://openalex.org/W2737081435"],"funded_outputs_count":6,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":290002.0,"currency":"EUR","amount_usd":387442.67,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"grant","funder_scheme":"CES","start_date":"2010-12-15","end_date":null,"start_year":2010,"end_year":null,"landing_page_url":"https://anr.fr/Projet-ANR-10-CESA-0014","doi":null,"provenance":"anr_opendata","lead_investigator":{"given_name":"Soazig","family_name":"LEMOINE","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITE DES ANTILLES-GUYANE","country":"Guadeloupe","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4875165537","primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.5706,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.5706,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-09-10T23:08:02.000Z"}