{"id":"https://openalex.org/G4844552325","display_name":"A multifunctional nanomaterial platform for reducing morbidity in medulloblastoma therapy","description":"This project will evaluate a novel biocompatible nanomaterial in preclinical studies to allow its clinical translation for NIR fluorescence and MRI image-guided surgery and sonodynamic therapy of medulloblastoma (MB). Based on our strong preliminary data, we hypothesize that this multifunctional nanomaterial platform can be transported across the blood-brain barrier and accumulate in MB tumors to enable their multimodal detection and safer therapy using non-ionizing low-intensity ultrasound. Translating this technology to the clinic would be transformative in managing MB by significantly reducing morbidities associated with surgery and chemoradiotherapy of MB tumors.","funder_award_id":"1r21ns135452-01","funder":{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","doi":"10.13039/100000002"},"funded_outputs":["https://openalex.org/W4416354472"],"funded_outputs_count":1,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":231489.0,"currency":"USD","amount_usd":231489.0,"amount_usd_basis":"usd_native","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R21","start_date":"2023-12-18","end_date":"2025-11-30","start_year":2023,"end_year":2025,"landing_page_url":"https://reporter.nih.gov/project-details/10786384","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"RAMON FRANCISCO","family_name":"BARAJAS","orcid":null,"role_start":null,"affiliation":{"name":"OREGON HEALTH & SCIENCE UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4844552325","primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.812,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.812,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}