{"id":"https://openalex.org/G4820006263","display_name":"Mechanisms of Genomic Imprinting","description":"We propose to test the role of DNA cytosine hydroxymethylation and chromatin in the erasure, establishment and maintenance of genomic imprints. Experiments using genome-wide mapping methods, novel allele- specific assays and mouse genetic tools will collectively help understand how DNA methylation, DNA hydroxymethylation and chromatin marks collaborate in the global epigenetic remodeling of germ cells and in erasing, establishing and maintaining genomic imprints. Correct global epigenetic remodeling and imprint resetting during embryonic-fetal germ cell development is essential for the health of the next generation and for future generations.","funder_award_id":"R01GM064378","funder":{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","doi":"10.13039/100000057"},"funded_outputs":["https://openalex.org/W16575186","https://openalex.org/W35154865","https://openalex.org/W1526107982","https://openalex.org/W1972658479","https://openalex.org/W1976227891","https://openalex.org/W1981711223","https://openalex.org/W1987406337","https://openalex.org/W1989358281","https://openalex.org/W2016600360","https://openalex.org/W2019369654","https://openalex.org/W2021223130","https://openalex.org/W2022131093","https://openalex.org/W2044017407","https://openalex.org/W2049883650","https://openalex.org/W2115304113","https://openalex.org/W2119955810","https://openalex.org/W2122112013","https://openalex.org/W2134771296","https://openalex.org/W2146352616","https://openalex.org/W2153169398","https://openalex.org/W2161470337","https://openalex.org/W2162972157","https://openalex.org/W2164428618","https://openalex.org/W2225733508","https://openalex.org/W2401256194","https://openalex.org/W2460495258","https://openalex.org/W2884175661","https://openalex.org/W2944955304","https://openalex.org/W3128452196","https://openalex.org/W4385469459","https://openalex.org/W4386474232","https://openalex.org/W4390053454"],"funded_outputs_count":32,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2002-04-01","end_date":"2018-04-30","start_year":2002,"end_year":2018,"landing_page_url":"https://reporter.nih.gov/project-details/7256615","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"PIROSKA EDIT","family_name":"SZAB\u00d3","orcid":null,"role_start":null,"affiliation":{"name":"VAN ANDEL RESEARCH INSTITUTE","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4820006263","primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9091,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9091,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"updated_date":"2026-11-05T03:01:09.000Z","created_date":"2026-10-09T19:56:01.000Z"}