{"id":"https://openalex.org/G4708635570","display_name":"CopN mechanism as a key to understanding Type Three Secretion in bacteria","description":"PUBLIC HEALTH RELEVANCE: Despite evident need, new antibiotics are not being developed at an adequate rate and most effort involves modifications of existing drugs, rather than identification and development of novel drug targets. An attractive target for the much-needed development of new antibiotic therapeutics is the Type Three Secretion System (T3SS), a virulence factor delivery machine that is conserved among over 25 species of Gram-negative bacteria (including category A, B, and C pathogens and new CDC category of urgent threats). We have discovered that a novel molecular scaffold is a critical feature of T3SS and will further elucidate its role in the hierarchy of secretion in multiple gram-negative bacteria as well as test the hypothesis that this molecular scaffold is a useful target for novel antibiotics.","funder_award_id":"R01AI108778","funder":{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","doi":"10.13039/100000060"},"funded_outputs":["https://openalex.org/W2076715530","https://openalex.org/W2081172289","https://openalex.org/W2345792152","https://openalex.org/W2475251964","https://openalex.org/W2734704033","https://openalex.org/W2770804597","https://openalex.org/W2981166728","https://openalex.org/W3092344833"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2014-07-01","end_date":"2021-06-30","start_year":2014,"end_year":2021,"landing_page_url":"https://reporter.nih.gov/project-details/9511713","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"BENJAMIN W","family_name":"SPILLER","orcid":null,"role_start":null,"affiliation":{"name":"VANDERBILT UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4708635570","primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"updated_date":"2026-10-30T03:00:55.000Z","created_date":"2026-10-09T19:56:01.000Z"}