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These enzymes will be validated as therapeutic targets individually or collectively using RNAi to invalidate the corresponding genes. Potential inhibitors (HDACi, HATi, HMTi, HDMi) will be screened by in silico docking to the modelled catalytic domains of the enzymes and collections of analogues will be tested for their ability to inhibit the activity of the corresponding recombinant proteins in high-throughput assays. We will also establish gene expression profiles corresponding to HME invalidation (by RNAi) and inhibition (using drug candidates in cultured larval stages (schistosomula) that will enable the determination of the specificity of action of the drugs. Finally, in vivo testing of the best candidates will be done in infected mice. In this way, during the study period we aim to develop a series of candidate molecules that can progress to clinical trials.","funder_award_id":"241865","funder":{"id":"https://openalex.org/F4320320300","display_name":"European Commission","doi":"https://doi.org/10.13039/501100000780"},"funded_outputs":["https://openalex.org/W1532707293","https://openalex.org/W1964248507","https://openalex.org/W1964296506","https://openalex.org/W1976717554","https://openalex.org/W1985678753","https://openalex.org/W2020043868","https://openalex.org/W2055423985","https://openalex.org/W2071931654","https://openalex.org/W2074364068","https://openalex.org/W2154127091","https://openalex.org/W2173295863","https://openalex.org/W2291959355","https://openalex.org/W2573151121","https://openalex.org/W2770182019","https://openalex.org/W2791203388","https://openalex.org/W2897192913"],"funded_outputs_count":16,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":3299998.0,"currency":"EUR","amount_usd":4753977.12,"amount_usd_basis":"daily_rate","recipients":[{"id":null,"display_name":"INOVACIA AB","ror":null,"country_code":"SE","roles":["partner"],"share":null,"basis":"funder_reported","asserted_by":"funder"},{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","roles":["lead"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I4210110092","display_name":"Inserm Transfert","ror":"https://ror.org/01wftfc57","country_code":"FR","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","roles":["partner"],"share":null,"basis":"affiliation_matcher","asserted_by":"funder"}],"recipient_countries":[{"country_code":"BR","share":0.3246,"amount_usd":1543140.97,"basis":"organisation_location"},{"country_code":"FR","share":0.3118,"amount_usd":1482290.07,"basis":"organisation_location"},{"country_code":"SE","share":0.183,"amount_usd":869977.81,"basis":"organisation_location"},{"country_code":"DE","share":0.1806,"amount_usd":858568.27,"basis":"organisation_location"}],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"grant","funder_scheme":"FP7 - 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