{"id":"https://openalex.org/G4281444591","display_name":"Improving bio-functions of polymer-based composites using hydrophilic aluminum silicate nanotubes","description":"The objective of this project was to prepare mechanically-flexible artificial bones, applicable to any bone-void shapes, with enhancing effect for bone regeneration through releasing inorganic ions such as calcium and silicate ions.Siloxane-containing calcium carbonate particles were embedded in poly(hydroxylalkanoate), and the resulting composites were shaped into a cotton-wool-like structure composed of ~10 um-fiber skeletons. The fibers were successfully coated with hydrophilic aluminum silicate nanotubes (imogolite).The materials could release calcium and silicate ions gradually, and showed an excellent protein adsorption ability and the healthy proliferation of osteoblast-like cells.","funder_award_id":"25630282","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W1997494781","https://openalex.org/W2013096550","https://openalex.org/W2016810419","https://openalex.org/W2048556231","https://openalex.org/W2054502953","https://openalex.org/W2092098955","https://openalex.org/W2104009005","https://openalex.org/W2131456729","https://openalex.org/W2139076273","https://openalex.org/W2181017485","https://openalex.org/W2228928005","https://openalex.org/W2342968100"],"funded_outputs_count":12,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4030000.0,"currency":"JPY","amount_usd":42693.93,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Challenging Exploratory Research","start_date":"2013-04-01","end_date":"2016-03-31","start_year":2013,"end_year":2016,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25630282/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Toshihiro","family_name":"Kasuga","orcid":null,"role_start":null,"affiliation":{"name":"Nagoya Institute of Technology","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000030233729","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5048824603","display_name":"Toshihiro Kasuga","orcid":"https://orcid.org/0000-0002-8745-8932"},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4281444591","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}