{"id":"https://openalex.org/G4240297672","display_name":"Synthetic DNA-free circuits for \u201cscarless\u201d programming of mammalian cells","description":"Relevance to Public Health This proposal aims to develop a new platform for the construction and delivery of protein-level circuits that program the behavior of mammalian cells while avoiding mutagenizing the host genome. This platform will facilitate diverse biomedical applications wherever it is necessary to eliminate or fix pathological cells, or generate new ones on demand in human patients. Specific examples include a \u201csmart\u201d virus that senses intracellular hallmarks and lyses cancer cells, and one that responds to different stages of cell fate reprogramming and dynamically and efficiently ushers cells through this process in vivo.","funder_award_id":"K99EB027723","funder":{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","doi":"10.13039/100000070"},"funded_outputs":["https://openalex.org/W4249558460","https://openalex.org/W7147086863"],"funded_outputs_count":2,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"career_development","funder_scheme":"K99","start_date":"2019-04-01","end_date":"2020-03-31","start_year":2019,"end_year":2020,"landing_page_url":"https://reporter.nih.gov/project-details/9721602","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"XIAOJING J","family_name":"GAO","orcid":null,"role_start":null,"affiliation":{"name":"CALIFORNIA INSTITUTE OF TECHNOLOGY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G4240297672","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"updated_date":"2026-10-30T03:00:55.000Z","created_date":"2026-10-09T19:56:01.000Z"}