{"id":"https://openalex.org/G3916632206","display_name":"Epigenetic Mechanisms of Neurodevelopment in Prenatal Alcohol Exposure","description":"PROJECT NARRATIVE Prenatal alcohol exposure (PAE) is a leading cause of preventable neurodevelopmental disability, and one contributory mechanism is impaired corticogenesis caused by alcohol\u2019s suppression of neural progenitor cell (NPC) proliferation. This project investigates molecular mechanisms that contribute to this impaired proliferation, and tests the ability of prenatal choline supplementation to prevent these changes. Study outcomes will clarify the mechanistic action of choline in improving neurodevelopmental outcomes in PAE, and thus inform choline intervention strategies.","funder_award_id":"1f32aa028684-01a1","funder":{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","doi":"10.13039/100000002"},"funded_outputs":["https://openalex.org/W4392379038","https://openalex.org/W4400025125"],"funded_outputs_count":2,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":59157.0,"currency":"USD","amount_usd":59157.0,"amount_usd_basis":"usd_native","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"F32","start_date":"2021-06-02","end_date":"2022-03-14","start_year":2021,"end_year":2022,"landing_page_url":"https://reporter.nih.gov/project-details/10313081","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"OLIVIA C","family_name":"RIVERA","orcid":null,"role_start":null,"affiliation":{"name":"UNIV OF NORTH CAROLINA CHAPEL HILL","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G3916632206","primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9924,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9924,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}