{"id":"https://openalex.org/G3913917543","display_name":"Engineering immunotherapeutic probiotics to mitigate irAE","description":"PROJECT NARRATIVE Cancer immunotherapies have demonstrated significant clinical success for subgroups of patients with varying malignancies. However, due in part to their systemic administration, therapeutic limitations include immune- related adverse effects and diminished efficacy due to poor tumor penetration. This proposal seeks to engineer immunotherapeutic probiotic bacteria that target primary cancers and associated metastases and locally deliver immunotherapy and adjuvants to stimulate systemic antitumor immunity with minimal side effects.","funder_award_id":"U01CA247573","funder":{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","doi":"https://doi.org/10.13039/100000054"},"funded_outputs":["https://openalex.org/W35301496","https://openalex.org/W4220702606","https://openalex.org/W4225394346","https://openalex.org/W4310251760","https://openalex.org/W4323636701","https://openalex.org/W4391044494","https://openalex.org/W4403451246","https://openalex.org/W4403782385","https://openalex.org/W7170075771","https://openalex.org/W7213433238"],"funded_outputs_count":10,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"cooperative_agreement","funder_scheme":"U01","start_date":"2020-01-21","end_date":"2024-12-31","start_year":2020,"end_year":2024,"landing_page_url":"https://reporter.nih.gov/project-details/10302262","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"NICHOLAS","family_name":"ARPAIA","orcid":null,"role_start":null,"affiliation":{"name":"COLUMBIA UNIV NEW YORK MORNINGSIDE","country":"UNITED STATES","ids":null},"author":{"id":"https://openalex.org/A5069204279","display_name":"Nicholas Arpaia","orcid":"https://orcid.org/0000-0002-0657-0528"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G3913917543","primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9907,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9907,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0059,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0017,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.84},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.961},{"id":"https://openalex.org/keywords/probiotic-engineering","display_name":"probiotic engineering","score":0.878},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.599},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.743},{"id":"https://openalex.org/keywords/systemic-antitumor-immunity","display_name":"systemic antitumor immunity","score":0.838},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.802}],"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.994,"display_name":"Good health and well-being"}],"institution_awarded":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-10-09T19:56:01.000Z"}