{"id":"https://openalex.org/G363242003","display_name":"Elucidation of the role of Wnt in tumor immunity of malignant glioma and its application to therapy","description":"We studied the relationship between intratumoral expression of Wnt and expression of PDL-1 and therapeutic effect, but the correlation between Wnt5a and PD-L1 expression in glioblastoma was weak, and the expression level of PD-L1 in patients with glioblastoma did not show the difference in survival time.In the analysis of Gene Expression Omnibus Database, there was PD-1 as a highly correlated gene candidate with Wnt-5a, but in vitro study the gene expression change related to immunosuppression of tumor cells by Wnt5a stimulation could not detected, and macrophage-mediated influence was no obvious in expression of immunity checkpoint-related genes.","funder_award_id":"15K10338","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2587216924","https://openalex.org/W2615157652","https://openalex.org/W2725132978","https://openalex.org/W2766293517","https://openalex.org/W2807616595","https://openalex.org/W2922294599","https://openalex.org/W2996534273","https://openalex.org/W3002338600","https://openalex.org/W7047296758"],"funded_outputs_count":9,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4810000.0,"currency":"JPY","amount_usd":40012.03,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2015-04-01","end_date":"2018-03-31","start_year":2015,"end_year":2018,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K10338/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Hirofumi","family_name":"HIRANO","orcid":null,"role_start":null,"affiliation":{"name":"Kagoshima University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000000264416","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5102835244","display_name":"Hirofumi Hirano","orcid":"https://orcid.org/0000-0002-1866-2737"},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G363242003","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}