{"id":"https://openalex.org/G3444529892","display_name":"A new approach to modeling ALS based on TBK1 mutation in mice","description":"PROJECT NARRATIVE ALS and FTD are neurodegenerative diseases that cause paralysis and dementia, respectively. Both diseases are progressive, which is unstoppable and invariably lead to death. The two are related diseases because the same gene mutations can cause either or both diseases. To accelerate understanding of these diseases, we propose a new approach to generate transgenic mouse models by delivering robust transgene expression in the spinal cord.","funder_award_id":"R21NS098497","funder":{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","doi":"10.13039/100000065"},"funded_outputs":["https://openalex.org/W2761044458","https://openalex.org/W2913329378"],"funded_outputs_count":2,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R21","start_date":"2016-07-01","end_date":"2019-06-30","start_year":2016,"end_year":2019,"landing_page_url":"https://reporter.nih.gov/project-details/9275555","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"ZUOSHANG","family_name":"XU","orcid":null,"role_start":null,"affiliation":{"name":"UNIV OF MASSACHUSETTS MED SCH WORCESTER","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G3444529892","primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8692,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8692,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"updated_date":"2026-11-04T03:01:03.000Z","created_date":"2026-10-09T19:56:01.000Z"}