{"id":"https://openalex.org/G327666152","display_name":"Genetic mechanisms of metformin's pro-longevity and anti-cancer effects","description":"Metformin is best known for its role in treating diabetes, but it promotes many other health benefits like inhibiting cancer growth and prolonging lifespan in model organisms. Despite these well described effects, the ways that metformin produces these effects remain unknown, and the highest doses of metformin used today may not be able to maximize these health benefits without undesirable side effects. This project will determine the genes that metformin acts through to produce these benefits, with the ultimate goal of exploiting metformin action to extend lifespan and reduce aging-related diseases such as cancer.","funder_award_id":"R01AG058256","funder":{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","doi":"10.13039/100000049"},"funded_outputs":["https://openalex.org/W29962263","https://openalex.org/W34610303","https://openalex.org/W2811312988","https://openalex.org/W2921000340","https://openalex.org/W2922624791","https://openalex.org/W2947142400","https://openalex.org/W2950350895","https://openalex.org/W2959585406","https://openalex.org/W2968124120","https://openalex.org/W2981305867","https://openalex.org/W2990248610","https://openalex.org/W3204809697","https://openalex.org/W4298326511","https://openalex.org/W4384558880","https://openalex.org/W4386045959","https://openalex.org/W4388826952","https://openalex.org/W4402141190","https://openalex.org/W4411048275","https://openalex.org/W4413006746","https://openalex.org/W4413974393","https://openalex.org/W4414532809","https://openalex.org/W7163176989","https://openalex.org/W7163935382","https://openalex.org/W7169149972"],"funded_outputs_count":24,"parent_awards":[],"sub_awards":[{"display_name":"Genetic mechanisms of metformin's pro-longevity and anti-cancer effects (sub-award to UNIVERSITY OF CALIFORNIA, SAN DIEGO)","id":"https://openalex.org/G9001192073","relationship":"sub_award","funder":{"display_name":"Massachusetts General Hospital","id":"https://openalex.org/F4320308349"},"asserted_by":"funder"},{"display_name":"Genetic mechanisms of metformin's pro-longevity and anti-cancer effects (sub-award to BROAD INSTITUTE, INC., THE)","id":"https://openalex.org/G9001222518","relationship":"sub_award","funder":{"display_name":"Massachusetts General Hospital","id":"https://openalex.org/F4320308349"},"asserted_by":"funder"}],"sub_awards_count":2,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2017-12-01","end_date":"2023-11-30","start_year":2017,"end_year":2023,"landing_page_url":"https://reporter.nih.gov/project-details/9607053","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"ALEXANDER A","family_name":"SOUKAS","orcid":null,"role_start":null,"affiliation":{"name":"MASSACHUSETTS GENERAL HOSPITAL","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G327666152","primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"updated_date":"2026-10-31T03:01:04.000Z","created_date":"2026-10-09T19:56:01.000Z"}