{"id":"https://openalex.org/G3086785","display_name":"Zarnu trakta mikrobiotu ietekm\u0113jo\u0161i faktori un saist\u012bba ar vesel\u012bbas st\u0101vokli z\u012bdai\u0146iem un mazu\u013ciem: prospekt\u012bva f\u0113\u010du mikrobiotas sast\u0101va metagenomiska anal\u012bze b\u0113rniem l\u012bdz 36 m\u0113ne\u0161u vecumam","description":"Zarnu mikrobiotai ir noz\u012bm\u012bga loma cilv\u0113ka vesel\u012bbas st\u0101vok\u013ca uztur\u0113\u0161an\u0101. Lai gan zarnu trakta koloniz\u0101cija s\u0101kas p\u0101rsvar\u0101 p\u0113c dzim\u0161anas, stabila mikrobiota veidojas pirmo dz\u012bves gadu laik\u0101. Mikrobiotu ietekm\u0113 da\u017e\u0101di faktori (di\u0113ta, vides faktori, medikamenti), tom\u0113r nav piln\u012bb\u0101 identific\u0113ti visi mikrobiotu ietekm\u0113jo\u0161ie faktori, da\u017e\u0101du faktoru mijiedarb\u012bba katr\u0101 indiv\u012bd\u0101, k\u0101 ar\u012b mikrobiotas stabiliz\u0101cijas vecums. F\u0113\u010du mikrobiota (FM) at\u0161\u0137iras indiv\u012bdiem ar da\u017e\u0101d\u0101m slim\u012bb\u0101m (t.sk., aler\u0123iju un funkcion\u0101liem gremo\u0161anas trakta trauc\u0113jumiem (FGID)). Tom\u0113r nav skaidrs, k\u0101das mikrobiotas izmai\u0146as ir veicin\u0101ju\u0161as slim\u012bbas att\u012bst\u012bbu, t\u0101d\u0113\u013c svar\u012bgi analiz\u0113t FM izmai\u0146as prospekt\u012bvi. Sekven\u0113\u0161anas meto\u017eu att\u012bst\u012bba \u013c\u0101vusi p\u0113t\u012bt zarnu trakta mikrobiotu, analiz\u0113jot FM sast\u0101vu, turkl\u0101t metogenomikas anal\u012bze sniedz iesp\u0113ju piln\u012bg\u0101k noteikt FM sast\u0101vu. P\u0113t\u012bjuma m\u0113r\u0137is ir analiz\u0113t FM dinamiskas izmai\u0146as, saist\u012bbu ar vides faktoriem un vesel\u012bbas st\u0101vokli b\u0113rniem l\u012bdz 36 m\u0113ne\u0161u vecumam. P\u0113t\u012bjuma uzdevumi ir analiz\u0113t - FM b\u0113rniem 0-6, 6-12 un 12-36 m\u0113ne\u0161u vecum\u0101; dz\u012bves, di\u0113tas, vides faktoru un vesel\u012bbas st\u0101vok\u013ca (aptauj\u0101jot) saist\u012bbu ar mikrobiotas sast\u0101vu; FM izmai\u0146as b\u0113rniem p\u0113c antibakteri\u0101las terapijas. P\u0113t\u012bjum\u0101 analiz\u0113sim FM rakstur\u012bg\u0101s izmai\u0146as da\u017e\u0101dos vecuma periodos, da\u017e\u0101du faktoru \u012bpatsvaru indiv\u012bdiem ar at\u0161\u0137ir\u012bgu mikrobiotas sast\u0101vu, k\u0101 ar\u012b mikrobiotas \u012bpatn\u012bbas b\u0113rniem ar aler\u0123iju un FGID.","funder_award_id":"lzp-2021/1-0275","funder":{"id":"https://openalex.org/F4320323269","display_name":"Latvijas Zin\u0101tnes Padome","doi":"10.13039/501100005375"},"funded_outputs":["https://openalex.org/W7162341534","https://openalex.org/W7212441990"],"funded_outputs_count":2,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":300000.0,"currency":"EUR","amount_usd":339780.0,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Fundament\u0101lo un lieti\u0161\u0137o p\u0113t\u012bjumu projekti (FLPP); Medic\u012bnas un vesel\u012bbas zin\u0101tnes","start_date":"2022-01-01","end_date":"2024-12-31","start_year":2022,"end_year":2024,"landing_page_url":"https://www.lzp.gov.lv/lv/projekts/zarnu-trakta-mikrobiotu-ietekmejosi-faktori-un-saistiba-ar-veselibas-stavokli-zidainiem-un-mazuliem-prospektiva-fecu-mikrobiotas-sastava-metagenomiska-analize-berniem-lidz-36-menesu-vecumam","doi":null,"provenance":"lzp_projects","lead_investigator":{"given_name":"Ilva","family_name":"Daugule","orcid":null,"role_start":null,"affiliation":{"name":"Liep\u0101jas Universit\u0101te","country":"LV","ids":null},"author":{"id":"https://openalex.org/A5030429889","display_name":"Ilva Daugule","orcid":"https://orcid.org/0000-0003-1312-4988"},"institutions":[{"id":"https://openalex.org/I4210107026","display_name":"University of Liep\u0101ja","ror":"https://ror.org/01gzemj61","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210107026"]}]},"co_lead_investigator":null,"investigators":[{"given_name":"Ilva","family_name":"Daugule","orcid":null,"role_start":null,"affiliation":{"name":"Liep\u0101jas Universit\u0101te","country":"LV","ids":null},"author":{"id":"https://openalex.org/A5030429889","display_name":"Ilva Daugule","orcid":"https://orcid.org/0000-0003-1312-4988"},"institutions":[{"id":"https://openalex.org/I4210107026","display_name":"University of Liep\u0101ja","ror":"https://ror.org/01gzemj61","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210107026"]}]}],"works_api_url":"https://api.openalex.org/works?filter=awards.id:G3086785","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I4210107026","display_name":"University of Liep\u0101ja","ror":"https://ror.org/01gzemj61","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210107026"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-10-01T17:31:12.000Z"}