{"id":"https://openalex.org/G3083328877","display_name":"Biology and Application of Platelet-Delivered Factor VIII","description":"PUBLIC HEALTH RELEVANCE: The most common inherited bleeding disorder, hemophilia A, is due to a deficiency of clotting factor (F) VIII. Care for this disorder is rapidly improving excpt for those who develop antibodies that block the ability of FVIII to correct bleeding and these antibodies are called inhibitors. We have developed a new treatment for such affected patients with inhibitors by packing the FVIII inside circulating platelets in the blood, but need to now tes the effectiveness of the delivery of FVIII within platelets in hemophilia A animal models, especially in the setting of inhibitors.","funder_award_id":"R01HL132557","funder":{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","doi":"10.13039/100000050"},"funded_outputs":["https://openalex.org/W2748810909","https://openalex.org/W2788009939","https://openalex.org/W2902121173","https://openalex.org/W3011477620","https://openalex.org/W3091277750","https://openalex.org/W3093533018","https://openalex.org/W3105446089"],"funded_outputs_count":7,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2016-05-01","end_date":"2020-04-30","start_year":2016,"end_year":2020,"landing_page_url":"https://reporter.nih.gov/project-details/9700716","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"MORTIMER","family_name":"PONCZ","orcid":null,"role_start":null,"affiliation":{"name":"CHILDREN'S HOSP OF PHILADELPHIA","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G3083328877","primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"updated_date":"2026-10-30T03:00:55.000Z","created_date":"2026-10-09T19:56:01.000Z"}