{"id":"https://openalex.org/G2579845599","display_name":"Mechanisms of FoxA1 Latent Enhancer Formation in Response to Proinflammatory Signaling in Hormone Dependent Cancers","description":"PUBLIC HEALTH RELEVANCE    Recent studies have highlighted the multitudinous avenues for crosstalk between the immune system and the endocrine system in cancer. It is known that inflammation is important for the development, progression and response to treatment of many cancers, and, in breast cancer, is known to play a key role in the development of resistance to hormone therapy. Therefore, this proposal is poised to define the molecular mechanisms that govern gene expression outcomes, and ultimately phenotypical outcomes, of cancer cells exposed to inflammatory and hormone signaling.","funder_award_id":"R00CA204628","funder":{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","doi":"10.13039/100000054"},"funded_outputs":["https://openalex.org/W2779442968","https://openalex.org/W2992086063","https://openalex.org/W3133886118"],"funded_outputs_count":3,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R00","start_date":"2017-02-17","end_date":"2020-01-31","start_year":2017,"end_year":2020,"landing_page_url":"https://reporter.nih.gov/project-details/9619338","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"HECTOR LUIS","family_name":"FRANCO","orcid":null,"role_start":null,"affiliation":{"name":"UNIV OF NORTH CAROLINA CHAPEL HILL","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G2579845599","primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.7835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.7835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}