{"id":"https://openalex.org/G2263293100","display_name":"Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian Cancer","description":"Project Narrative Resistant ovarian cancers are a terminal disease that cannot be cured with existing therapeutics. We propose to develop robust nanoscale coordination polymers (NCPs) for the co-delivery of chemotherapeutic agents (cisplatin or cisplatin plus gemcitabine) and small interfering RNA (siRNA) cocktails targeting multi-drug resistance (MDR) pathways. By identifying three MDR genes with the highest expression levels in patients' tumors, NCPs carrying chemotherapeutic agents and siRNAs targeting these genes will be designed as personalized therapies for treating these patients with resistant OCa.","funder_award_id":"5r01ca216436-05","funder":{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","doi":"10.13039/100000002"},"funded_outputs":["https://openalex.org/W2810505935","https://openalex.org/W2883164386","https://openalex.org/W2897416241","https://openalex.org/W2941337719","https://openalex.org/W2952331148","https://openalex.org/W2981487371","https://openalex.org/W3080665922","https://openalex.org/W3115172909","https://openalex.org/W3128758274","https://openalex.org/W3131028886","https://openalex.org/W3202389905","https://openalex.org/W3204833948","https://openalex.org/W4200378702","https://openalex.org/W4283363656","https://openalex.org/W4302362959","https://openalex.org/W4307407956","https://openalex.org/W4309330740","https://openalex.org/W4316174560","https://openalex.org/W4319337543","https://openalex.org/W4323660571","https://openalex.org/W4361225572","https://openalex.org/W4382749384","https://openalex.org/W4394695002","https://openalex.org/W7172440640"],"funded_outputs_count":24,"parent_awards":[],"sub_awards":[{"funder":{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago"},"id":"https://openalex.org/G9001249362","asserted_by":"funder","relationship":"sub_award","display_name":"Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of (sub-award to MAYO CLINIC)"}],"sub_awards_count":1,"amount":415717.0,"currency":"USD","amount_usd":415717.0,"amount_usd_basis":"usd_native","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2018-02-15","end_date":"2023-01-31","start_year":2018,"end_year":2023,"landing_page_url":"https://reporter.nih.gov/project-details/10329991","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"WENBIN","family_name":"LIN","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF CHICAGO","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G2263293100","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"updated_date":"2026-10-17T03:01:12.000Z","created_date":"2026-10-09T19:56:01.000Z"}