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In this study, we have revealed that TLS-CHOP represses an anticancer cytokine MDA-7/IL-24 expression, and represses miR-486 that targets a tumor cell growth and metastasis activator PAI-1 In addition, a novel molecular pathway that induces expression of a tumorigenesis-related protein PRG4 has been suggested.","funder_award_id":"22590367","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W1977078318","https://openalex.org/W2017853784","https://openalex.org/W2020604945","https://openalex.org/W2066342751","https://openalex.org/W2068051800","https://openalex.org/W2110498887"],"funded_outputs_count":6,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":3900000.0,"currency":"JPY","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"programme_rule","tier":4},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":null,"end_date":null,"start_year":null,"end_year":null,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22590367/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kosuke","family_name":"OIKAWA","orcid":null,"role_start":null,"affiliation":{"name":"Wakayama Medical University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000070348803","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5012362577","display_name":"Kosuke Oikawa","orcid":"https://orcid.org/0000-0002-2549-8883"},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G2118945587","primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9648,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9648,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0069,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myxoid-liposarcoma","display_name":"myxoid liposarcoma","score":0.987},{"id":"https://openalex.org/keywords/oncogenic-mechanisms","display_name":"oncogenic mechanisms","score":0.718},{"id":"https://openalex.org/keywords/mda-7-il-24","display_name":"MDA-7/IL-24","score":0.944},{"id":"https://openalex.org/keywords/mir-486","display_name":"miR-486","score":0.989},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.988},{"id":"https://openalex.org/keywords/proteoglycan-4","display_name":"proteoglycan 4","score":0.994},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.904},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.823}],"sustainable_development_goals":[{"score":0.9537,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"institution_awarded":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}