{"id":"https://openalex.org/G209130786","display_name":"Kombinovan\u00e1 lie\u010dba glioblast\u00f3mu temozolomidom a sekund\u00e1rnymi metabolitmi li\u0161ajn\u00edkov","description":"Glioblast\u00f3m (GBM) je mozgov\u00fd n\u00e1dor, charakterizovan\u00fd svojim agres\u00edvnym rastom do okolit\u00e9ho tkaniva, pr\u00edtomnos\u0165ou n\u00e1dorov\u00fdch kme\u0148ov\u00fdch buniek, rezistenciou na lie\u010dbu a zlou progn\u00f3zou. Cie\u013eom predkladan\u00e9ho projektu je zefekt\u00edvni\u0165 chemoterapiu temozolomidom pomocou sekund\u00e1rnych metabolitov li\u0161ajn\u00edkov, atranor\u00ednu (ATR) a kyseliny gyroforovej (GA), eliminova\u0165 ved\u013eaj\u0161ie \u00fa\u010dinky temozolomidu, ako aj pok\u00fasi\u0165 sa o potla\u010denie rezistencie n\u00e1dorov\u00fdch buniek na tento typ lie\u010dby. Budeme pritom sledova\u0165 zmeny synt\u00e9zy prote\u00ednov rezistencie (enz\u00fdmu MGMT, regul\u00e1tora p53 - prote\u00ednu MDM2 a vybran\u00fdch ABC-transportn\u00fdch syst\u00e9mov). V \u010fal\u0161om postupe zist\u00edme farmakokinetiku ATR a GA, ako aj ich celkov\u00fd \u00fa\u010dinok na metabolizmus. Pok\u00fasime sa tie\u017e definova\u0165 vz\u0165ah medzi prolifera\u010dnou aktivitou kme\u0148ov\u00fdch buniek a vznikom GBM. Tak\u00fdto komplexn\u00fd experiment\u00e1lny pr\u00edstup by mal umo\u017eni\u0165 z\u00edska\u0165 nov\u00e9 poznatky o rezistencii GBM na lie\u010dbu a t\u00fdm prispie\u0165 k zlep\u0161eniu progn\u00f3zy pre\u017eitia pri tomto type n\u00e1doru.","funder_award_id":"1/0658/20","funder":{"id":"https://openalex.org/F4320323641","display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi":"10.13039/501100006109"},"funded_outputs":["https://openalex.org/W3000338299","https://openalex.org/W3025704615","https://openalex.org/W4286462577","https://openalex.org/W4309008596","https://openalex.org/W4311491569","https://openalex.org/W4313891019","https://openalex.org/W4388913151","https://openalex.org/W4404041515"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":99677.0,"currency":"EUR","amount_usd":111977.14,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"grant","funder_scheme":"PR\u00cdRODN\u00c9 VEDY, MATEMATICK\u00c9 VEDY, INFORMATICK\u00c9 VEDY A KYBERNETICK\u00c9 VEDY / Biologick\u00e9 vedy / Fyziol\u00f3gia \u017eivo\u010d\u00edchov","start_date":"2020-01-01","end_date":"2023-12-31","start_year":2020,"end_year":2023,"landing_page_url":"https://www.skcris.sk/sk/register-projektov/995f43e1-571f-4fa4-ae86-ab29b0e8e9cb","doi":null,"provenance":"vega_sk","lead_investigator":{"given_name":"Ter\u00e9zia","family_name":"Kiskov\u00e1","orcid":null,"role_start":null,"affiliation":{"name":"Univerzita Pavla Jozefa \u0160af\u00e1rika v Ko\u0161iciach; Univerzita Pavla Jozefa \u0160af\u00e1rika v Ko\u0161iciach, Pr\u00edrodovedeck\u00e1 fakulta; Univerzita veterin\u00e1rskeho lek\u00e1rstva a farm\u00e1cie v Ko\u0161iciach; Univerzita Pavla Jozefa \u0160af\u00e1rika v Ko\u0161iciach, Lek\u00e1rska fakulta","country":"Slovakia","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G209130786","primary_topic":null,"topics":null,"institution_awarded":[],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-07-13T04:27:42.000Z"}