{"id":"https://openalex.org/G204708698","display_name":"Investigation of oral mucosal inflammatory disease developing mechanism via Toll-like receptor","description":"Oral keratinocytes and fibroblasts may augment host defense and inflammatory responses against oral microorganisms invasion. However, it remains unclear whether oral keratinocytes and fibroblasts produce specific inflammatory proteins in response to Pathogen-associated molecular patterns (PAMPS) and associated with oral mucosal inflammatory diseases.  Our results showed that oral keratinocytes and fibroblasts  expressed mRNA of TLRs 1-10. IL-8 and CXCL10 production from oral keratinocytes and fibroblasts was induced by treatment with various TLR agonisits.  These findings suggest that recognition of microorganism-derived pathogen in oral keratinocytes and fibroblasts by TLR may have important role to orchestrate host immune responses and promoting hyper/hypo reactions related to oral inflammatory diseases via production of various chemokines.","funder_award_id":"23792346","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W24495175","https://openalex.org/W1500353374","https://openalex.org/W2050416651"],"funded_outputs_count":3,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4160000.0,"currency":"JPY","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"Grant-in-Aid for Young Scientists (B)","start_date":null,"end_date":null,"start_year":null,"end_year":null,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23792346/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Hiromi","family_name":"NISHI","orcid":null,"role_start":null,"affiliation":{"name":"Hiroshima University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000070403558","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5011937874","display_name":"Hiromi Nishi","orcid":"https://orcid.org/0000-0003-0741-9886"},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G204708698","primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9233,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9233,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0652,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0068,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.853},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.906},{"id":"https://openalex.org/keywords/oral-keratinocytes","display_name":"oral keratinocytes","score":0.996},{"id":"https://openalex.org/keywords/oral-fibroblasts","display_name":"oral fibroblasts","score":0.998},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.961},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.898},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.999},{"id":"https://openalex.org/keywords/chemokine-production","display_name":"chemokine production","score":0.89},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.755},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.805},{"id":"https://openalex.org/keywords/oral-inflammatory-diseases","display_name":"oral inflammatory diseases","score":0.689}],"sustainable_development_goals":[{"score":0.9476,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"institution_awarded":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}