{"id":"https://openalex.org/G2040407196","display_name":"Elucidation of Ankrd1 function in renal cancer and development of new therapeutic strategy to overcome drug resistance","description":"We created a human renal cancer cell line, resistant to the drug rapamycin, which inhibits mTOR, which is one of the therapeutic targets for renal cancer, and investigated the difference betwwen the genes expressed in non-resistant and resistant strains. As a result, Ankrd1 was one of the genes strongly expressed in the resistant strain.When this Ankrd1 was knocked down, a decrease in the expression of BCL2 family proteins that suppress cell death and a cell growth inhibitory effect were observed. This study has shown that Ankrd1 may be a novel therapeutic target for renal cancer.","funder_award_id":"18K16684","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W4409928287"],"funded_outputs_count":1,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4160000.0,"currency":"JPY","amount_usd":39081.48,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"Grant-in-Aid for Early-Career Scientists","start_date":"2018-04-01","end_date":"2020-03-31","start_year":2018,"end_year":2020,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16684/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Sei","family_name":"Naito","orcid":null,"role_start":null,"affiliation":{"name":"Yamagata University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000000431643","type":"nrid","asserted_by":"kaken"}]}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G2040407196","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-07-13T04:17:19.000Z"}