{"id":"https://openalex.org/G202371969","display_name":"Gene Transcripts and Proteomics in Families with Platelet Hyperaggregation","description":"PUBLIC HEALTH RELEVANCE: Platelets in the circulating blood can stick together (aggregate), clot and cause heart attack or stroke. We will develop a better understanding of the process through sequencing genes that are transcribed in platelets and comparing the patterns of gene expression in people whose platelets have very high levels of aggregation to those with normal aggregation. The results will lead to better and more specific treatments to reduce platelet aggregation in people who are at risk for complications of arterial occlusions.","funder_award_id":"R01HL118356","funder":{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","doi":"10.13039/100000050"},"funded_outputs":["https://openalex.org/W2996024184","https://openalex.org/W3094388913","https://openalex.org/W3170079927","https://openalex.org/W4406390327","https://openalex.org/W7161563992"],"funded_outputs_count":5,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2014-04-01","end_date":"2019-03-31","start_year":2014,"end_year":2019,"landing_page_url":"https://reporter.nih.gov/project-details/9258474","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"LEWIS C","family_name":"BECKER","orcid":null,"role_start":null,"affiliation":{"name":"JOHNS HOPKINS UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G202371969","primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6305,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6305,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"updated_date":"2026-10-28T03:01:04.000Z","created_date":"2026-10-09T19:56:01.000Z"}