{"id":"https://openalex.org/G1964330545","display_name":"Analysis of D-serine dynamics for the development of new drug against neuropsychiatric disorders","description":"In the mammalian brain, L-serine produced in astrocytes is transported to neurons and changes into D-serine by serine racemase (SRR). D-Serine returns to astrocyte, and this process is hypothesized as \u201cserine shuttle\u201d based on the in vitro experiments. However, this hypothesis is not examined in vivo. In this study, we generated novel two transgenic mouse strains inducing the D-serine degradation in astrocytes- or neurons-specific manner. Both transgenic mouse strains showed significant reduction of D-serine in the brain, suggesting the novel mechanism of D-serine transport from astrocytes to neurons. Furthermore, we generated another novel mouse strain detecting SRR gene expression with bioluminescence in vivo. Using this mouse strain, we identified some compounds affecting the gene expression of SRR.","funder_award_id":"18K06888","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2940543349","https://openalex.org/W2968675634","https://openalex.org/W2973884780","https://openalex.org/W2993156713","https://openalex.org/W3015962146","https://openalex.org/W3083652050","https://openalex.org/W3085214946","https://openalex.org/W3085512855","https://openalex.org/W3093254870","https://openalex.org/W3137115628","https://openalex.org/W3138727301","https://openalex.org/W4220662082","https://openalex.org/W4235123809","https://openalex.org/W4313584505"],"funded_outputs_count":14,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4420000.0,"currency":"JPY","amount_usd":41524.07,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2018-04-01","end_date":"2021-03-31","start_year":2018,"end_year":2021,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K06888/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Hisashi","family_name":"Mori","orcid":null,"role_start":null,"affiliation":{"name":"University of Toyama","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000000239617","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5050127204","display_name":"Hisashi Mori","orcid":"https://orcid.org/0000-0001-9743-2456"},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1964330545","primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9971,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9971,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0008,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-serine","display_name":"D-serine","score":0.998},{"id":"https://openalex.org/keywords/serine-racemase","display_name":"serine racemase","score":0.994},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.905},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.774},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.739},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.721},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.827},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.598}],"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.624}],"institution_awarded":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}