{"id":"https://openalex.org/G1960078460","display_name":"Elucidation of acute toxicity of drugs by real-time metabolome analysis and multivariate time-series analysis","description":"In this study, our research team have developed a real-time metabolome analytical technique using probe electrospray ionization tandem mass spectrometry (PESI/MS/MS) with time-series multivariate analyses. We optimized analytical conditions for real-time mass spectrometry, achieving successfully monitoring of 40 metabolites in a living mouse. Our research team has also developed a data pipeline using the R software, and this data pipeline can automatically execute bioinformatics analyses such as multivariate analysis. Moreover, we have developed a new approach using a state space model based on Bayesian statistical modeling for time-series data obtained from real-time monitoring. Finally, we applied this technique to a living mouse, demonstrating the practicality of our technique.","funder_award_id":"18K10122","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W32954186","https://openalex.org/W2809827016","https://openalex.org/W2971224543","https://openalex.org/W3019633907","https://openalex.org/W3021146622","https://openalex.org/W3082021724","https://openalex.org/W3092019062","https://openalex.org/W3128378828","https://openalex.org/W3138478319"],"funded_outputs_count":9,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4420000.0,"currency":"JPY","amount_usd":41524.07,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2018-04-01","end_date":"2021-03-31","start_year":2018,"end_year":2021,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K10122/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kei","family_name":"Zaitsu","orcid":null,"role_start":null,"affiliation":{"name":"Nagoya University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000030700546","type":"nrid","asserted_by":"kaken"}]}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1960078460","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-07-13T04:17:19.000Z"}