{"id":"https://openalex.org/G194065166","display_name":"Glycoengineering insect cells for commercial recombinant glycoprotein production","description":"PUBLIC HEALTH RELEVANCE:   Most recombinant protein drugs, or biologics, are manufactured using mammalian cells that can add the sugars required for these proteins to have their clinical effect. However, mammalian cell systems have some limitations and new biologics manufacturing platforms are needed to overcome this problem and to address the need for increased manufacturing capacity. This project will extend an academic lab effort, which has demonstrated that genetically engineered insect cells are potentially excellent alternative biologics manufacturing platforms, to the marketplace. New engineering strategies will be used to create insect cell lines optimized for commercial applications under conditions that will facilitate their future validation as new biologics manufacturing tools.                    ","funder_award_id":"R43GM102982","funder":{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","doi":"10.13039/100000057"},"funded_outputs":["https://openalex.org/W1066175468","https://openalex.org/W2005931422","https://openalex.org/W2080888355","https://openalex.org/W2288165644","https://openalex.org/W2404555666","https://openalex.org/W2405822729","https://openalex.org/W2414739967","https://openalex.org/W2743466609","https://openalex.org/W2763185647","https://openalex.org/W2767944831","https://openalex.org/W2775248391","https://openalex.org/W2802781227","https://openalex.org/W3215156757","https://openalex.org/W4245176100"],"funded_outputs_count":14,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R43","start_date":"2013-09-30","end_date":"2016-07-31","start_year":2013,"end_year":2016,"landing_page_url":"https://reporter.nih.gov/project-details/8733179","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"CHRISTOPH","family_name":"GEISLER","orcid":null,"role_start":null,"affiliation":{"name":"GLYCOBAC, LLC","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G194065166","primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[],"updated_date":"2026-10-17T03:01:12.000Z","created_date":"2026-10-09T19:56:01.000Z"}