{"id":"https://openalex.org/G1933502172","display_name":"Developing macrophage reprogramming mRNA nanocarriers for initial clinical testing","description":"Project Narrative It is of key interest in cancer research to create ways to reprogram tumor-associated macrophages (TAMs) from a pro-tumor (M2-like) to an anti-tumor (M1-like) phenotype and thereby induce immune effects that can bring about tumor regression. However, at present, there are no methods that can enable physicians to rationally and selectively reprogram TAMs for therapeutic purposes. In this proposal, we are optimizing an off- the-shelf nanodrug that carries in vitro-transcribed mRNA to genetically reprogram immunosuppressive macrophages (M2-like TAMs) to express tumor-clearing (M1-like) phenotypes as a new approach to treat otherwise incurable ovarian cancer and, ultimately, other types of malignancies as well.","funder_award_id":"R01CA263524","funder":{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","doi":"10.13039/100000054"},"funded_outputs":["https://openalex.org/W3155985241","https://openalex.org/W3193478854","https://openalex.org/W4200451376"],"funded_outputs_count":3,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2021-08-01","end_date":"2025-07-31","start_year":2021,"end_year":2025,"landing_page_url":"https://reporter.nih.gov/project-details/10884875","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"MATTHIAS","family_name":"STEPHAN","orcid":null,"role_start":null,"affiliation":{"name":"FRED HUTCHINSON CANCER CENTER","country":"UNITED STATES","ids":null},"author":{"id":"https://openalex.org/A5063788144","display_name":"Matthias T. Stephan","orcid":"https://orcid.org/0000-0001-8310-0100"},"institutions":[]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1933502172","primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[],"updated_date":"2026-11-10T03:01:11.000Z","created_date":"2026-10-09T19:56:01.000Z"}