{"id":"https://openalex.org/G192405422","display_name":"Pharmacogenomics study of anti-tuberculosis drugs in the Asian population","description":"We have been conducting International Collaborative TB Research in Asia. Anti-TB drug-induced liver injury (AT-DILI) is a main reason of treatment failure. A total of 138 Thai TB patients including 53 AT-DILI cases and 366 Japanese TB patients including 73 AT-DILI cases were enrolled. The odds ratios of N-acetyltransferase 2 (NAT2) slow acetylator (SA) status with AT-DILI were 8.80 (95% confidence interval (CI) 4.01-19.31, P-value = 1.53*10-8) in Thais and 4.32 (95%CI 1.93-9.66, p=5.56*10-5) in Japanese. Our results demonstrated that the acetylator status of NAT2 is an important determinant for AT-DILI in Asia. We performed first-phase genome-wide association study to search for the additional genetic factors. International meta-analysis and cost-effectiveness analysis may provide data to support the individualization of anti-TB treatment in Asian TB patients based on genotyping of the NAT2 and additional genes.","funder_award_id":"24406010","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W1964176156","https://openalex.org/W2022439949","https://openalex.org/W2345978938","https://openalex.org/W2474725771","https://openalex.org/W2753264205","https://openalex.org/W3126763814"],"funded_outputs_count":6,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":17290000.0,"currency":"JPY","amount_usd":210775.14,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (B)","start_date":"2012-04-01","end_date":"2015-03-31","start_year":2012,"end_year":2015,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24406010/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Katsushi","family_name":"TOKUNAGA","orcid":null,"role_start":null,"affiliation":{"name":"The University of Tokyo","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000040163977","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5040367383","display_name":"Katsushi Tokunaga","orcid":"https://orcid.org/0000-0001-5501-0503"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G192405422","primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9492,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9492,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0411,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0025,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.89},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.977},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.937},{"id":"https://openalex.org/keywords/n-acetyltransferase-2","display_name":"N-acetyltransferase 2","score":0.985},{"id":"https://openalex.org/keywords/asian-populations","display_name":"Asian populations","score":0.527},{"id":"https://openalex.org/keywords/thai-patients","display_name":"Thai patients","score":0.847},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":1.0},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.842},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.707}],"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"institution_awarded":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}