{"id":"https://openalex.org/G1908666086","display_name":"Dual Leucine Zipper Kinase (DLK) as a Mediator of Retinal Ganglion Cell Injury","description":"PUBLIC HEALTH RELEVANCE: Through high content and siRNA screening programs we have identified the protein kinase DLK as playing an important role in RGC death following injury. Inhibition of DLK provides a potential mechanism to promote RGC survival in glaucoma and in other forms of optic nerve disease. In this application, we propose to determine the ability of DLK inhibition to promote RGC survival in an animal model of glaucoma, study the mechanism of DLK regulation and action, and develop more selective DLK inhibitors.","funder_award_id":"R01EY023754","funder":{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","doi":"10.13039/100000053"},"funded_outputs":["https://openalex.org/W27102165","https://openalex.org/W1596255224","https://openalex.org/W2039352658","https://openalex.org/W2132846716","https://openalex.org/W2265638154","https://openalex.org/W2310282476","https://openalex.org/W2345282885","https://openalex.org/W2409724652","https://openalex.org/W2509821482","https://openalex.org/W2596116678","https://openalex.org/W2599401074","https://openalex.org/W2632293652","https://openalex.org/W2747172588","https://openalex.org/W2761739377","https://openalex.org/W2793093998","https://openalex.org/W4223491796"],"funded_outputs_count":16,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2013-09-01","end_date":"2018-08-31","start_year":2013,"end_year":2018,"landing_page_url":"https://reporter.nih.gov/project-details/9127253","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"DONALD J.","family_name":"ZACK","orcid":null,"role_start":null,"affiliation":{"name":"JOHNS HOPKINS UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1908666086","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}