{"id":"https://openalex.org/G1906294249","display_name":"Development of single-molecule measurement with angstrom precision","description":"We have developed an optical microscopic single-molecule method based on the scattering imaging of plasmonic metal nanoparticles, and achieved atomic-level (angstrom-level) localization precision and microsecond time resolution. In addition, the developed method has been successfully applied to linear and rotary molecular motors such as kinesin and V1-ATPase to elucidate their chemo-mechanical coupling mechanism and elementary process of motion in detail. Furthermore, we have developed a dual-color, high-speed/high-precision single-molecule measurement method using silver and gold nanoparticles as probes, and a method estimating chemical state-dependent free energy profile from the single-molecule trajectory of the movement of molecular motor.","funder_award_id":"18H02418","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2901604670","https://openalex.org/W2972801573","https://openalex.org/W3001309462","https://openalex.org/W3035443475","https://openalex.org/W3039422301","https://openalex.org/W3165336012"],"funded_outputs_count":6,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":17420000.0,"currency":"JPY","amount_usd":163653.69,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (B)","start_date":"2018-04-01","end_date":"2021-03-31","start_year":2018,"end_year":2021,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18H02418/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Ryota","family_name":"IINO","orcid":null,"role_start":null,"affiliation":{"name":"Institute for Molecular Science","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000070403003","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5067727024","display_name":"Ryota Iino","orcid":"https://orcid.org/0000-0003-0110-5704"},"institutions":[{"id":"https://openalex.org/I4210143791","display_name":"Institute for Molecular Science","ror":"https://ror.org/04wqh5h97","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210143791"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1906294249","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I4210143791","display_name":"Institute for Molecular Science","ror":"https://ror.org/04wqh5h97","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210143791"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}