{"id":"https://openalex.org/G182239","display_name":"Tunable DNA-nanostructure to induce NK-mediated killing of tumor cells","description":" Narrative We propose to develop a novel tumor-killing DNA-nanostructure, in which multimeric cell- recognition aptamers will be assembled onto tunable and programmable DNA-nanoscaffolds to engage immune cells to attack tumor cells.","funder_award_id":"R21CA141021","funder":{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","doi":"10.13039/100000054"},"funded_outputs":["https://openalex.org/W2091691458","https://openalex.org/W2152432960","https://openalex.org/W2337147508"],"funded_outputs_count":3,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R21","start_date":"2010-05-01","end_date":"2013-04-30","start_year":2010,"end_year":2013,"landing_page_url":"https://reporter.nih.gov/project-details/8067094","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"YUNG","family_name":"CHANG","orcid":null,"role_start":null,"affiliation":{"name":"ARIZONA STATE UNIVERSITY-TEMPE CAMPUS","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G182239","primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.7296,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.7296,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"updated_date":"2026-10-28T03:01:04.000Z","created_date":"2026-10-09T19:56:01.000Z"}