{"id":"https://openalex.org/G1685642366","display_name":"High-Throughput Measurements of RNA-Mediated Regulation of Gene Expression and Oncogenesis","description":"Project Narrative RNA-binding proteins (RBPs) control most aspects of post-transcriptional gene regulation and cause several types of human cancers when mutated, which disrupts their interactions with many different RNAs. Currently, it is not well understood how RBPs are organized to regulate the expression of the RNAs they bind, and which specific domains within them have regulatory potential that is sensitive to mutation. In this work, I will develop and use a high-throughput recruitment assay to identify functional \u2018effector\u2019 domains within RBPs, link them to their molecular and cellular mechanisms of regulating RNA, and determine how mutations within them lead to cancer developmen.","funder_award_id":"1f30ca287739-01","funder":{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","doi":"10.13039/100000002"},"funded_outputs":["https://openalex.org/W4387358485","https://openalex.org/W4404016077","https://openalex.org/W4409786015","https://openalex.org/W4416866313","https://openalex.org/W7119159947"],"funded_outputs_count":5,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":51237.0,"currency":"USD","amount_usd":51237.0,"amount_usd_basis":"usd_native","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"F30","start_date":"2024-04-01","end_date":"2027-03-31","start_year":2024,"end_year":2027,"landing_page_url":"https://reporter.nih.gov/project-details/10823373","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"ABBY","family_name":"THURM","orcid":null,"role_start":null,"affiliation":{"name":"STANFORD UNIVERSITY","country":"UNITED STATES","ids":null},"author":{"id":"https://openalex.org/A5072786777","display_name":"Abby R. Thurm","orcid":"https://orcid.org/0000-0002-1819-3192"},"institutions":[]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1685642366","primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"updated_date":"2026-11-10T03:01:11.000Z","created_date":"2026-10-09T19:56:01.000Z"}