{"id":"https://openalex.org/G1567310941","display_name":"Functional consequences of cancer mutations","description":" In synergy with large scale cancer genomics projects we plan to elucidate the role of thousands of protein mutations observed in many human tumor samples. The Online Mutation Assessor (OMA), a computational resource, will combine detailed knowledge about the evolution and structure of proteins and their interactions in biomolecular pathways and provide researchers with an estimate of the functional impact of protein mutations observed in individual patients. When translated to clinical practice, detailed knowledge about an individual's mutation profile will enable a more personalized approach to cancer therapy.","funder_award_id":"R01CA132744","funder":{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","doi":"10.13039/100000054"},"funded_outputs":["https://openalex.org/W1899117259","https://openalex.org/W2065323708","https://openalex.org/W2111326065","https://openalex.org/W2114843025","https://openalex.org/W2149441684"],"funded_outputs_count":5,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2009-04-01","end_date":"2014-01-31","start_year":2009,"end_year":2014,"landing_page_url":"https://reporter.nih.gov/project-details/8210896","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"CHRIS","family_name":"SANDER","orcid":null,"role_start":null,"affiliation":{"name":"SLOAN-KETTERING INST CAN RESEARCH","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1567310941","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I39965400","display_name":"Kettering University","ror":"https://ror.org/03rcspa57","country_code":"US","type":"education","lineage":["https://openalex.org/I39965400"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}