{"id":"https://openalex.org/G139954591","display_name":"Generation of multifunctionalized nucleophilic carbenes","description":"With the aim of developing a method that allows the generation of nucleophilic carbenes at a cryogenic temperature, we focused on an iminium salt derived from \u03b2-silyl-\u03b1,\u03b2-epoxyaldehydes, which can potentially generate a nucleophilic carbene via deprotonation of a proton on an iminium carbon atom, ring-opening of epoxide and Brook rearrangement of the resulting \u03b1-silyl alkoxide. We devised a method for the preparation of the substrates and found that some structural modification of the substrates is required to successfully generate a nucleophilc carbene. During the attempt, we also found that 1,n-dipole (n \u22603), a new class of synthons, can serve important intermediates in the synthesis of complex molecules.","funder_award_id":"22790011","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2003482802","https://openalex.org/W2033650191","https://openalex.org/W2149553630","https://openalex.org/W2951970586"],"funded_outputs_count":4,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4030000.0,"currency":"JPY","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"Grant-in-Aid for Young Scientists (B)","start_date":null,"end_date":null,"start_year":null,"end_year":null,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22790011/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Michiko","family_name":"SASAKI","orcid":null,"role_start":null,"affiliation":{"name":"Hiroshima University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000030379888","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5000149579","display_name":"Michiko Sasaki","orcid":"https://orcid.org/0000-0002-6277-4349"},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G139954591","primary_topic":{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.4263,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.4263,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13253","display_name":"Photolysis and Reactive Intermediates","score":0.2002,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11790","display_name":"N-Heterocyclic Carbenes in Organic and Inorganic Chemistry","score":0.1747,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleophilic-carbenes","display_name":"nucleophilic carbenes","score":0.998},{"id":"https://openalex.org/keywords/iminium-salts","display_name":"iminium salts","score":0.812},{"id":"https://openalex.org/keywords/epoxide-ring-opening","display_name":"epoxide ring opening","score":0.772},{"id":"https://openalex.org/keywords/brook-rearrangement","display_name":"Brook rearrangement","score":0.99},{"id":"https://openalex.org/keywords/deprotonation","display_name":"deprotonation","score":0.784},{"id":"https://openalex.org/keywords/cryogenic-temperatures","display_name":"cryogenic temperatures","score":0.579},{"id":"https://openalex.org/keywords/synthons","display_name":"synthons","score":0.633}],"sustainable_development_goals":[],"institution_awarded":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}