{"id":"https://openalex.org/G1071007010","display_name":"Structural study of the novel transcription mechanism essential for root development of higher plants","description":"Two GRAS proteins, SHR and SCR, cooperatively direct asymmetric cell division and the patterning of root cell types by transcriptional control in conjunction with BIRD/IDD transcription factors. The crystal structures of the SHR-SCR binary and JKD-SHR-SCR ternary complexes has been determined. Each GRAS domain comprises one \u03b1/\u03b2 core subdomain with an \u03b1-helical cap that mediates heterodimerization by forming an intermolecular helix bundle. The \u03b1/\u03b2 core subdomain of SHR forms the BIRD binding groove, which specifically recognizes the zinc fingers of JKD. We identified a conserved SHR-binding motif in 13 BIRD/IDD transcription factors. Our results establish a structural basis for GRAS-GRAS and GRAS-BIRD interactions and provide valuable clues towards our understanding of these regulators, which are involved in plant-specific signalling networks.","funder_award_id":"25440025","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2084778320","https://openalex.org/W2588183626"],"funded_outputs_count":2,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":5200000.0,"currency":"JPY","amount_usd":55088.94,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2013-04-01","end_date":"2017-03-31","start_year":2013,"end_year":2017,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25440025/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Yoshinori","family_name":"Hirano","orcid":null,"role_start":null,"affiliation":{"name":"Nara Institute of Science and Technology","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000050452529","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5085684647","display_name":"Yoshinori Hirano","orcid":"https://orcid.org/0000-0001-9888-1616"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G1071007010","primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9899,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9899,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}