{"id":"https://openalex.org/G10080705","display_name":"Development of refined detection system for mature and active IL-1b family proteins","description":"Inflammation is a common risk factor for common diseases, such as cancer, and autoimmune disease. Interleukin\u20101b and IL-18 are pro-inflammatory cytokines assigned to the IL-1 family because of its structural homology, receptor utilization and signal transduction pathways. Both of IL-1b and IL-18 are initially synthesized as inactive precursors and the cleavage required for processing into mature forms is mainly mediated by pro-inflammatory caspases following the activation and assembly of macromolecular complexes called inflammasomes. Detection of these neoepitopes of mature forms should provide a unique and sensitive indicator of inflammatory action.A refined detection system for mature and active IL-1b and IL-18 could be developed by utilizing our developed neoepitope mAbs in combination with epitope-different mAbs. Such a system might be useful in inflammasome biology, and for diagnostic and therapeutic strategies for inflammatory diseases.","funder_award_id":"17K08983","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W31775905","https://openalex.org/W2614927819","https://openalex.org/W2740409075","https://openalex.org/W2744290485","https://openalex.org/W2766631448","https://openalex.org/W2777868256","https://openalex.org/W2795981565","https://openalex.org/W2806849769","https://openalex.org/W2807280589","https://openalex.org/W2807540041","https://openalex.org/W2808969968","https://openalex.org/W2809094831","https://openalex.org/W2810683019","https://openalex.org/W2886750678","https://openalex.org/W2907391355","https://openalex.org/W2991611679","https://openalex.org/W3009738134"],"funded_outputs_count":17,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4810000.0,"currency":"JPY","amount_usd":43014.4,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2017-04-01","end_date":"2020-03-31","start_year":2017,"end_year":2020,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K08983/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Urano","family_name":"Takeshi","orcid":null,"role_start":null,"affiliation":{"name":"Shimane University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000070293701","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5001962229","display_name":"Takeshi Urano","orcid":"https://orcid.org/0000-0003-3383-3554"},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G10080705","primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}