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Angetrieben durch technologische Fortschritte in der Hochdurchsatz-Analyse von mikrobiellen Spezies und Gemeinschaften auf molekularer Ebene, er\u00f6ffnen sich der mikrobiologischen Forschung beispiellose M\u00f6glichkeiten, aktuellen und neu entstehenden Herausforderungen zu begegnen. Neben dem Beitrag zur Bek\u00e4mpfung globaler Gesundheitsbedrohungen wie der Resistenz gegen antimikrobielle Mittel und viralen Pandemien, spielt die Mikrobiologie eine Schl\u00fcsselrolle in Bereichen wie Landwirtschaft und Abfallwirtschaft, Wasseraufbereitung, der Sanierung von \u00d6kosystemen, sowie der Diagnose, Behandlung und Pr\u00e4vention von unterschiedlichsten Krankheiten. Diesem breiten Potenzial entsprechend wurden weltweit Milliarden von Euro in Mikrobiota-Forschungsprogramme investiert. Obwohl sie unabh\u00e4ngig voneinander durchgef\u00fchrt werden, stehen viele dieser Projekte in engem Zusammenhang. Deutschland verf\u00fcgt jedoch derzeit \u00fcber keine Infrastruktur, um die Ergebnisse solcher Projekte zu verkn\u00fcpfen. Daher gehen potenzielle Synergien verloren bzw. werden nicht realisiert. NFDI4Microbiota wird eine gro\u00dfe, heterogene Forschungsgemeinschaft unterst\u00fctzen, indem es die Interaktion zwischen Forschern f\u00f6rdert, spezielle Schulungen anbietet und die Generierung, Verwaltung, gemeinsame Nutzung und Wiederverwendung von mikrobiellen Daten und deren Interpretation erleichtert. NFDI4Microbiota wird dies durch Vernetzung der Forschungs-Communitys und Training erreichen. Zentral daf\u00fcr ist die Schaffung eines Cloud-basierten Systems f\u00fcr die Speicherung, Integration und Analyse von mikrobiellen Daten, insbesondere von Omics-Daten, um diese konsistent und reproduzierbar allen Bereichen der Biowissenschaften zug\u00e4nglich zu machen. 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