{"id":"https://openalex.org/W4230572514","doi":"https://doi.org/10.21203/rs.2.488/v2","title":"Ocular surface analysis and automatic non-invasive assessment of tear film breakup location, extension and progression in patients with glaucoma","display_name":"Ocular surface analysis and automatic non-invasive assessment of tear film breakup location, extension and progression in patients with glaucoma","publication_year":2019,"publication_date":"2019-12-18","ids":{"openalex":"https://openalex.org/W4230572514","doi":"https://doi.org/10.21203/rs.2.488/v2"},"language":"en","primary_location":{"id":"doi:10.21203/rs.2.488/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.488/v2","pdf_url":"https://assets.researchsquare.com/files/rs-487/v2/manuscript.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://assets.researchsquare.com/files/rs-487/v2/manuscript.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036288799","display_name":"\u0410. \u0413\u0443\u0430\u0440\u043d\u0438\u0435\u0440\u0438","orcid":"https://orcid.org/0000-0003-2871-3339"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Adriano Guarnieri","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046057652","display_name":"Elena Carnero","orcid":"https://orcid.org/0000-0001-9828-2197"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Carnero","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833352","display_name":"Anne\u2010Marie Bleau","orcid":null},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anne-Marie Bleau","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025223500","display_name":"Nicol\u00e1s L\u00f3pez de Aguileta Casta\u00f1o","orcid":"https://orcid.org/0000-0002-7766-7650"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s L\u00f3pez de Aguileta Casta\u00f1o","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017864481","display_name":"Marcos Llorente","orcid":"https://orcid.org/0000-0001-6536-1286"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marcos Llorente Ortega","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039852231","display_name":"Javier Moreno\u2010Monta\u00f1\u00e9s","orcid":"https://orcid.org/0000-0002-6623-6783"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Moreno-Monta\u00f1\u00e9s","raw_affiliation_strings":["Universidad de Navarra"],"affiliations":[{"raw_affiliation_string":"Universidad de Navarra","institution_ids":["https://openalex.org/I4210135003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5036288799"],"corresponding_institution_ids":["https://openalex.org/I4210135003"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.7017074823379517},{"id":"https://openalex.org/keywords/extension","display_name":"Extension (predicate logic)","score":0.6999903321266174},{"id":"https://openalex.org/keywords/breakup","display_name":"Breakup","score":0.6680265665054321},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.632788896560669},{"id":"https://openalex.org/keywords/optometry","display_name":"Optometry","score":0.4683603048324585},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.45876258611679077},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3631930351257324},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13779544830322266},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.08783328533172607},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.062010496854782104}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7017074823379517},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.6999903321266174},{"id":"https://openalex.org/C2777871205","wikidata":"https://www.wikidata.org/wiki/Q100926628","display_name":"Breakup","level":2,"score":0.6680265665054321},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.632788896560669},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.4683603048324585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45876258611679077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3631930351257324},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13779544830322266},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.08783328533172607},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.062010496854782104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.2.488/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.488/v2","pdf_url":"https://assets.researchsquare.com/files/rs-487/v2/manuscript.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.2.488/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.488/v2","pdf_url":"https://assets.researchsquare.com/files/rs-487/v2/manuscript.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4230572514.pdf","grobid_xml":"https://content.openalex.org/works/W4230572514.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W2010842159","https://openalex.org/W2017695421","https://openalex.org/W2018885276","https://openalex.org/W2055370551","https://openalex.org/W2069248407","https://openalex.org/W2153289041","https://openalex.org/W2160122170","https://openalex.org/W2229725876","https://openalex.org/W2313744378","https://openalex.org/W2339286115","https://openalex.org/W2416084544","https://openalex.org/W2419523617","https://openalex.org/W2560689497","https://openalex.org/W2582799095","https://openalex.org/W2607064205","https://openalex.org/W2612366831","https://openalex.org/W2620348519","https://openalex.org/W2621361010","https://openalex.org/W2737642784","https://openalex.org/W2738160893","https://openalex.org/W2739221391","https://openalex.org/W2770218576","https://openalex.org/W2783264923","https://openalex.org/W2889625468","https://openalex.org/W2903493717","https://openalex.org/W3024880883"],"related_works":["https://openalex.org/W2352892738","https://openalex.org/W2350945386","https://openalex.org/W1978976512","https://openalex.org/W2253256329","https://openalex.org/W2762157816","https://openalex.org/W2902826102","https://openalex.org/W2082183064","https://openalex.org/W3007282748","https://openalex.org/W4238442536","https://openalex.org/W4323039687"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tear":[2],"film":[3,28,80,250,269],"stability":[4],"is":[5,18,271],"the":[6,26,61,132,140,151,157,178,183,196,199,202,211,216,224,229,234,256,261],"key":[7],"event":[8],"in":[9,53,139,150,156,167,177,182,201,210,215,228,233,255,260,276,280],"ocular":[10],"surface":[11],"diseases.":[12],"The":[13,88,264],"purpose":[14],"of":[15,25,67,78,142,198],"this":[16,68],"study":[17],"to":[19,72,94,130],"evaluate":[20],"spatial":[21],"and":[22,47,56,76,118,137,154,164,169,187,190,220,223,238,245,273],"temporal":[23],"progression":[24,77,89],"tear":[27,37,79,249,268],"break-up":[29,38,81,85,251],"using":[30,112],"an":[31],"automatic":[32],"non-invasive":[33],"device.":[34,64],"Methods":[35],"Non-invasive":[36],"time":[39],"(NITBUT)":[40],"parameters,":[41],"such":[42],"as":[43,100],"First":[44,91],"NITBUT":[45,49,243],"(F-NITBUT)":[46],"Average":[48],"(A-NITBUT),":[50],"were":[51,110,253],"evaluated":[52],"132":[54],"glaucoma":[55,158,170,179,203,212,230,257],"87":[57],"control":[58,152,168,184,217,235,262],"eyes":[59,278],"with":[60,82],"Keratograph":[62],"5M":[63],"Further":[65],"analysis":[66],"data":[69,117],"was":[70,98,128,147,162,175,191,207,226],"used":[71,129],"determine":[73],"size,":[74],"location":[75],"automatically":[83],"identified":[84],"areas":[86],"(BUA).":[87],"from":[90],"BUA":[92,96],"(F-BUA)":[93],"total":[95],"(T-BUA)":[97],"expressed":[99],"Dry":[101],"Area":[102],"Growth":[103],"Rate":[104],"(DAGR).":[105],"Differences":[106],"between":[107,134],"both":[108],"groups":[109],"analysed":[111],"Student":[113],"t-test":[114],"for":[115,122],"parametric":[116,135],"Mann-Whitney":[119],"U":[120],"test":[121],"non-parametric":[123,143],"data.":[124],"Pearson's":[125],"correlation":[126],"coefficient":[127],"assess":[131],"relationship":[133],"variables":[136],"Spearman":[138],"case":[141],"variables.":[144],"Results":[145],"F-NITBUT":[146],"11.43\u00b17.83":[148],"seconds":[149,166],"group":[153,159,180,185,204,213,218,231,236,258],"8.17\u00b15.73":[155],"(P=0.010).":[160],"A-NITBUT":[161],"14.04\u00b17.21":[163],"11.82\u00b16.09":[165],"groups,":[171],"respectively":[172],"(P=0.028).":[173],"F-BUA":[174],"higher":[176,209],"than":[181,214,232,259,279],"(2.73":[186],"2.28;":[188],"P=0.022)":[189],"more":[192,247],"frequently":[193],"located":[194],"at":[195],"centre":[197],"cornea":[200],"(P=0.039).":[205],"T-BUA":[206],"also":[208],"(13.24%":[219],"9.76%;":[221],"P=0.012)":[222],"DAGR":[225,265],"steeper":[227],"(34.38\u00ba":[237],"27.15\u00ba;":[239],"P=0.009).":[240],"Conclusions":[241],"Shorter":[242],"values":[244],"bigger,":[246],"central":[248],"locations":[252],"observed":[254],"group.":[263],"indicates":[266],"that":[267],"rupture":[270],"bigger":[272],"increases":[274],"faster":[275],"glaucomatous":[277],"normal":[281],"eyes.":[282]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2025-10-10T00:00:00"}
